We accelerate the path from research to patient care.
Cutting-Edge Clinical Diagnostics
At Targeted Bioscience, we are proud to partner with George Mason University's CAP/CLIA-certified Clinical Diagnostics Laboratory (GMCDL) and Clinical Proteomics Laboratory (CPL). Our mission is to bring advanced medical technologies to clinical practice, focusing on personalized medicine and innovative diagnostic solutions.
Innovative Technologies for Rigorous Testing and Validation
Our lab is equipped to provide comprehensive diagnostic services, leveraging advanced proteomic mass spectrometry, RT-PCR diagnostics, and spatial tissue imaging technologies. We excel in the verification of biomarkers and the development of customized test panels tailored to the unique needs of clinical trials.
Proteomics Mass Spectrometry
Equipped with cutting-edge instruments like the Bruker timsTOF and ThermoFisher Exploris 480.
RT-PCR Diagnostics
High-throughput testing capabilities, including digital PCR and SNP genotyping.
Spatial Tissue Imaging
State-of-the-art DakoCytomation Autostainers and PhenoCycler-Fusion technology for tissue profiling.
Next Generation Sequencing (NGS)
High-throughput sequencing technology, enabling precise genomic and transcriptomic profiling.
Custom Assay and Biomarkers Solutions
Extensive capabilities in evaluating and verifying novel proteomic technologies and biomarkers, we accelerate the path from research to patient care
Isolation of extracellular vesicles directly from tissues to track patient response and tumor progression, reverse immune suppression within the tumor
A suite of software applications including a universal whole slide image viewer, remote collaboration interface with image annotation and messaging, and data analysis tools driven by AI for multimodal analysis (multi-omic and image) insights
Bringing Precision to Clinical Trials and Diagnostics
We have collaborated with leading institutions on a variety of critical projects, from cancer clinical trials to COVID-19 testing. Our contributions include:
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Cancer Clinical Trials: Supported by partnerships with organizations such as Genentech and NIH.
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COVID-19 Response: Over 250,000 PCR tests with a 24-hour turnaround.
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Infectious & Neurological Disease Testing: Backed by Gates Foundation and VA funding.
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Tissue Microenvironment Research: Advanced spatial profiling for cancer and other diseases.
Meet Our Experts: Bringing Decades of Experience to Advanced Diagnostics
Our team is led by some of the foremost experts in cancer research, clinical trial design, and proteomics. With extensive backgrounds in medical diagnostics, our leadership is dedicated to ensuring cutting-edge research is seamlessly integrated into our testing services.
Advanced Laser Capture Microdissection Service for Precision Research
Targeted Bioscience's laser capture microdissection service revolutionizes spatial biology research through our proprietary AccuLift™ system, delivering unparalleled precision for gene expression analysis and molecular profiling. Our cutting-edge laser capture microdissection technology enables researchers to isolate specific cells from heterogeneous tissue with single-cell resolution, providing direct microscopic visualization for optimal target selection.
Our comprehensive laser capture microdissection service supports diverse research applications, from gene expression profiling to proteomic analysis. The AccuLift™ platform seamlessly processes both fresh frozen and formalin fixed paraffin embedded tissue sections, enabling researchers to isolate specific cells while preserving surrounding tissue integrity. This automated sample preparation technique integrates with downstream analysis workflows including next generation sequencing, mass spectrometry, and Sanger sequencing.
The contact-free laser microdissection process ensures contamination-free sample collection directly into standard collection vessels or petri dish stage formats. Our laser capture microdissection lcm workflow preserves nucleic acids, proteins, and individual cells for comprehensive molecular characterization. Whether targeting specific regions within complex tissues or isolating live cells for functional studies, our microdissection services deliver research-grade purity essential for accurate downstream analysis.
Partnered with George Mason University's CAP/CLIA-certified laboratories, our laser capture technology supports cdna library generation, proteomics discovery, rna transcript profiling, and dna genotyping applications. For researchers requiring precision isolation of cells from heterogeneous tissue samples, our laser capture microdissection services accelerate discovery through advanced technique implementation designed specifically for research use.
Comprehensive Gene Expression Analysis Through Laser Capture Technology
Transform your molecular research with Targeted Bioscience's specialized gene expression analysis capabilities powered by precision laser capture microdissection. Our AccuLift™ system enables targeted isolation of cells of interest directly from complex tissue architectures, providing the foundation for robust gene expression profiling and proteomics analysis.
Our laser capture methodology preserves cellular integrity while eliminating cross-contamination from surrounding unwanted cells, ensuring high-quality dna, rna, and proteins for accurate molecular characterization. The system's advanced optics and precision laser cutting technology facilitate collection of pure cell populations essential for reliable gene expression studies and biomarker discovery.
The integrated workflow supports immediate processing for analysis or long-term storage, maintaining sample viability for diverse downstream analysis applications. From single-cell studies to comprehensive proteomics research, our laser microdissection services provide the precision and reliability demanded by cutting-edge molecular research initiatives.
Advanced Extracellular Vesicles Service for Tissue Microenvironment Analysis
Targeted Bioscience's extracellular vesicles service revolutionizes biomarker discovery through our proprietary Interstitial Fluid Collection Kit, enabling direct isolation of extracellular vesicles from living tissue microenvironments. Our innovative approach to analyze extracellular vesicles provides unprecedented access to tissue-derived molecular information unavailable through conventional body fluid samples or cell culture supernatant methods.
Comprehensive Extracellular Vesicles Isolation and Characterization
Our comprehensive extracellular vesicles service integrates advanced isolation techniques with cutting-edge analytical capabilities. The platform processes extracellular vesicles evs from various sample types including fresh tissue biopsies, biological fluids, and stem cells for regenerative medicine applications. Unlike traditional ultra centrifugation and size exclusion chromatography methods, our system preserves extracellular vesicle proteins and ev cargo integrity while eliminating contamination from apoptotic bodies and cellular debris.
High Sensitivity Detection and Proteomic Analysis
Partnered with George Mason University's CAP/CLIA-certified laboratories, our high sensitivity detection platform supports multiplex flow cytometry, nanoparticle tracking analysis, and electron microscopy characterization of extracellular vesicles derived from tissue sources. Our advanced proteomic analysis capabilities enable comprehensive examination of nucleic acids, proteins, and lipids within vesicles, facilitating biomarker discovery across various diseases through quantitative analysis and absolute quantification methods.
Advanced Data Analysis for Molecular Characterization
Our sophisticated data analysis platform identifies transporting proteins and various biomolecules critical for understanding cellular communication and intercellular communication pathways. The integrated workflow supports small rnaseq, phosphorylation analysis, and glycosylation profiling of extracellular vesicle proteins. Through advanced enrichment techniques and data analysis methods, researchers can identify important roles of vesicles in biological processes and disease pathways. Our cryo electron microscopy services provide detailed characterization and quantification of isolated vesicles, supporting research applications from basic cellular communication studies to clinical biomarker validation in alignment with international society standards for extracellular vesicles research.
